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It's a question that arises with virtually every major new finding in science or medicine: What makes a result reliable enough to be taken seriously? The answer has to do with statistical significance -- but also with judgments about what standards make sense in a given situation.

Last week, Biz Stone appeared on the Howard Stern Show, where the satellite-radio host grilled the Twitter cofounder on virtually every aspect of the social network. One of the funnier parts of the interview came when Stern asked Stone about how much money he's made from Twitter, to which Stone replied that he makes a perfectly good salary, has a mortgage, and leases a Mini.