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It was the largest and most important investigation of treatments for high blood pressure ever conducted, with a monumental price tag to match. U.S.

The stock of drug-maker Abbott Laboratories tanked May 26 after results were published on a trial of whether the B vitamin niacin can help prevent heart disease and strokes. The immediate follow-on question is whether the premise on which that trial was based, the so-called HDL Hypothesis, has just received another coffin nail